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Downstream metabolic improvements — changes in cortisol, insulin sensitivity, or body composition — require longer windows of 6–12 weeks, and depend substantially on whether DSIP is used as part of a broader supervised metabolic protocol rather than in isolation

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it diminishes when used in conjugation reactions with xenobiotics through the glutathione S-transferase pathway or by forming GSSG due to its reactivity with free radicals and ROS [47]

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