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doi: 10.3389/fphar.2023.1122632 Received 13 December 2022 Accepted 13 March 2023 Published 27 March 2023 Volume 14 - 2023 Edited by Enrico Sangiovanni, University of Milan, Italy Reviewed by Ayaz Shahid, Western University of Health Sciences, United States Andres A

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Interestingly, detailed biochemical studies revealed novel properties of PGA1–GSH adducts, such as a higher turnover number (Kcat) for PGA E 9-ketoreductase than its substrate [162] and the inhibition of cAMP efflux in RBCs [163]